Leg Ulcers

Clinical evidence and case reports on the use of Abilar® wound balm in chronic venous leg ulcers.

Clinical Study

A prospective 6-month study evaluated the healing rate of leg ulcers in 40 patients (35 with preoperative chronic ulcers and 5 with postoperative Surgical Site Infections) following peripheral rearterialization — surgical procedures to restore blood flow — for Critical Limb Ischaemia (CLI). Participants were randomized to receive either Abilar® 10% resin salve (n=20) or medical honey salve (n=20) for at-home topical care. Healing was assessed clinically or through linear regression analysis of progressive wound size reduction during scheduled follow-up visits.

Key Findings

In the "per protocol" analysis of patients with sufficient data, 77% (17 of 22) achieved treatment success, showing objective evidence of either complete healing or a significant trend toward healing. When excluding surgical site infections, 74% of preoperative chronic foot ulcers healed following revascularization and the use of the antiseptic salves. The mean observed healing time for clinically closed ulcers was 61 ± 41 days.

Journal article cover — Peripheral Rearterialization for Critical Limb Ischaemia and Antiseptic Resin or Honey Salve

Reference

Auvinen T, Haapakorva E, Sipponen A, Mäkinen K, Jokinen JJ. Peripheral Rearterialization for Critical Limb Ischaemia and Antiseptic Resin or Honey Salve in Postoperative Ulcer Care Results in Healing Rate Of Leg Ulcers in Three Quarters of Cases. A Prospective Clinical Follow-up of 35 Patients with Preoperative Chronic Ulcer and 5 Patients with Post-Surgery Wound (Surgical Site Infection). Journal of Surgery. 2020;5:1328. doi:10.29011/2575-9760.001328

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Case Studies

Case 1

Female 80 years old with severe rheumatoid arthritis and refractory venous leg ulcer for several years. The ulcer was operated on twice and treated continually with various topical wound care products without success. Abilar® Wound Balm treatment was initiated and salve was applied once a day. After 3 months, signs of small, epithelialized islets can be seen. The ulcer was completely healed after 7 months of Abilar® treatment.

Pressure ulcer before Abilar® treatment, 3 months progress, and 7 months after complete healing

Pressure ulcer before Abilar® treatment, 3 months progress, and 7 months after complete healing.

Reference Non-public

Case 2

The 68-year-old woman has a history of varicose veins and severe coronary artery disease. Risk factors are smoking and obesity. She presented with non-healing leg ulcers of mixed venous and arterial origin almost a year ago. After percutaneous coronary intervention, bilateral venous crossectomy, right femoral artery and popliteal 2nd segment thrombendarterectomy, and femoropopliteal bypass surgery were performed. The leg wound was rapidly drying up, covered with black necrosis, which, with the use of Abilar®, was detachable within one month; the necrosis and plaque were increasingly dissolving, and granulation was starting.

Chronic mixed arterial and venous leg ulcers, and 1 month later

Chronic mixed arterial and venous leg ulcers, and 1 month later.

Reference Tímea Hevér. Initial Experience with Norway Spruce (Picea Abies) Resin. Biomed J Sci & Tech Res. 2024;57(4). doi:10.26717/BJSTR.2024.57.009043

Case 3

The 80-year-old patient developed a growing ulcer on his leg after a blow years ago for an unknown reason. The wound was continuously covered with a biofilm layer, which could not be broken down for three months, despite various dressings and treatment methods. Abilar® treatment started on the patient gradually broke down the biofilm and within a month and a half the wound started to granulate.

Chronic ankle ulcer of unknown cause, and 1.5 months later

Chronic ankle ulcer of unknown cause, and 1,5 months later.

Reference Tímea Hevér. Initial Experience with Norway Spruce (Picea Abies) Resin. Biomed J Sci & Tech Res. 2024;57(4). doi:10.26717/BJSTR.2024.57.009043

Case 4

An 80-year-old female patient has a rapidly growing, extremely painful wound caused by pyoderma gangrenosum. After two months of immunosuppressive treatment, a gradual improvement started. Now, after two months of Abilar® use, the wound bed has levelled out and the wound edges have started to exfoliate spectacularly.

Painful atypical leg ulcer caused by pyoderma gangrenosum, and 2 months later

Painful atypical leg ulcer caused by pyoderma gangrenosum, and 2 months later.

Reference Tímea Hevér. Initial Experience with Norway Spruce (Picea Abies) Resin. Biomed J Sci & Tech Res. 2024;57(4). doi:10.26717/BJSTR.2024.57.009043